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Article

Disruption of the murine PIASx gene results in reduced testis weight

1 Jun 2005

Abstract excerpt

PIASx belongs to the PIAS protein family, the members of which modulate activities of several transcription factors and act as E3 ligases in the sumoylation pathway. The PIASx gene is highly expressed in testis, suggesting a role in spermatogenesis. To investigate the function of PIASx in vivo, we have disrupted the PIASx gene in mice. Interestingly, the knockout mice were viable and fertile. Despite the normal...

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PMID: 15956336
DOI: 10.1677/jme.1.01666

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