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Article

Impaired fertility and spermiogenetic disorders with loss of cell adhesion in male mice expressing an interfering Rap1 mutant.

Molecular biology of the cell - 1 Apr 2007

Aivatiadou Evanthia, Mattei Elisabetta, Ceriani Michela, Tilia Leila, Berruti Giovanna

Abstract excerpt

The guanosine trisphosphatase Rap1 serves as a critical player in signal transduction, somatic cell proliferation and differentiation, and cell-cell adhesion by acting through distinct mechanisms. During mouse spermiogenesis, Rap1 is activated and forms a signaling complex with its effector, the serine-threonine kinase B-Raf. To investigate the functional role of Rap1 in male germ cell differentiation, we...

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Identifiers

PMID: 17314400
DOI: 10.1091/mbc.e06-10-0902
PMCID: PMC1838989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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