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Article

Spermatogonial Depletion in Adult Pin1-Deficient Mice1

1 Dec 2003

Abstract excerpt

Spermatogonia in the mouse testis arise from early postnatal gonocytes that are derived from primordial germ cells (PGCs) during embryonic development. The proliferation, self-renewal, and differentiation of spermatogonial stem cells provide the basis for the continuing integrity of spermatogenesis. We previously reported that Pin1-deficient embryos had a profoundly reduced number of PGCs and that Pin1 was...

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PMID: 12930711
DOI: 10.1095/biolreprod.103.020859

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