Development of a functional assay for Ca2+ release activity of IP3R and expression of an IP3R gene fragment in the baculovirus-insect cell system.

doi:10.1016/s0378-1119(97)80001-7

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Article

Development of a functional assay for Ca2+ release activity of IP3R and expression of an IP3R gene fragment in the baculovirus-insect cell system.

Gene - 29 Apr 1997

Raghu P, Habib S, Hasnain S E, Hasan G

Abstract excerpt

Receptor-stimulated phosphoinositide (PI) hydrolysis is an important and ubiquitous mechanism of intracellular signaling. Inositol 1,4,5-trisphosphate (IP3), generated by phosphoinositide (PI) hydrolysis, binds to and gates an intracellular Ca2+ channel, the IP3 receptor (IP3R), which is therefor...

Topics

Animals
Baculoviridae
Calcium
Calcium Channels
Cell Line
Cloning, Molecular
DNA
Drosophila
Genes, Dominant
Inositol 1,4,5-Trisphosphate Receptors
Phenotype
Receptors, Cytoplasmic and Nuclear
Spodoptera

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