The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development.

doi:10.1534/g3.115.024307

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Article

The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development.

G3 (Bethesda, Md.) - 27 Nov 2015

Dean Derek M, Maroja Luana S, Cottrill Sarah, Bomkamp Brent E, Westervelt Kathleen A, Deitcher David L

Abstract excerpt

Inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP3; this limits IP3R activation by reducing IP3 levels, and...

Topics

Alleles
Animals
Base Sequence
Chromosome Mapping
Drosophila
Drosophila Proteins
Epistasis, Genetic
Gene Order
Inositol 1,4,5-Trisphosphate Receptors
Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Phenotype

Phosphotransferases (Alcohol Group Acceptor)

Protein Binding

Quantitative Trait Loci

RNA Interference

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 26613949
DOI: 10.1534/g3.115.024307
PMCID: PMC4751550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26613949-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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