Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.

doi:10.1126/scisignal.aad6281

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Article

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.

Science signaling - 5 Apr 2016

Alzayady Kamil J, Wang Liwei, Chandrasekhar Rahul, Wagner Larry E, Van Petegem Filip, Yule David I

Abstract excerpt

Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are tetrameric intracellular Ca(2+)-release channels with each subunit containing a binding site for IP3in the amino terminus. We provide evidence that four IP3molecules are required to activate the channel under diverse conditions. Comparing the concentration-response relationship for binding and Ca(2+)release suggested that IP3Rs are maximally occupied by...

Topics

Animals
Binding Sites
CRISPR-Cas Systems
Calcium
Calcium Signaling
Cell Line
HEK293 Cells
Humans
Inositol 1,4,5-Trisphosphate
Inositol 1,4,5-Trisphosphate Receptors
Models, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Structure

Mutation

Protein Binding

Protein Domains

Protein Multimerization

Protein Subunits

Source

Open in PubMed Open full text

Identifiers

PMID: 27048566
DOI: 10.1126/scisignal.aad6281
PMCID: PMC4850551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-27048566-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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