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Article

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.

Science signaling - 5 Apr 2016

Alzayady Kamil J, Wang Liwei, Chandrasekhar Rahul, Wagner Larry E, Van Petegem Filip, Yule David I

Abstract excerpt

Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are tetrameric intracellular Ca(2+)-release channels with each subunit containing a binding site for IP3in the amino terminus. We provide evidence that four IP3molecules are required to activate the channel under diverse conditions. Comparing the concentration-response relationship for binding and Ca(2+)release suggested that IP3Rs are maximally occupied by...

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Identifiers

PMID: 27048566
DOI: 10.1126/scisignal.aad6281
PMCID: PMC4850551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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