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Article

Active TGF-β signaling and decreased expression of PTEN separates angiosarcoma of bone from its soft tissue counterpart.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2013

Verbeke Sofie L J, Bertoni Franco, Bacchini Patrizia, Oosting Jan, Sciot Raf, Krenács Tibor, Bovée Judith V M G

Abstract excerpt

Angiosarcomas constitute a heterogeneous group of highly malignant vascular tumors. Angiosarcoma of bone is rare and poorly characterized. For angiosarcoma of soft tissue, some pathways seem to be involved in tumor development. Our aim was to evaluate the role of these pathways in angiosarcoma of...

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Source

Identifiers

PMID: 23599148
DOI: 10.1038/modpathol.2013.56

Genes

PTEN
KIT
MDM2
BCL2
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23599148-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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