Article
MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas.
The American journal of pathology - 1 Nov 1998
Zietz C, Rössle M, Haas C, Sendelhofert A, Hirschmann A, Stürzl M, Löhrs U
Abstract excerpt
The endothelium is one of the largest cellular compartments of the human body and has a high proliferative potential. However, angiosarcomas are among the rarest malignancies. Despite this interesting contradiction, data on growth and angiogenesis control mechanisms of angiosarcomas are scarce. I...
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA Mutational Analysis
- Endothelial Growth Factors
- Female
- Genes, p53
- Hemangiosarcoma
- Humans
- Lymphokines
- Male
- Middle Aged
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Proto-Oncogene Mas
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2