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Article

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics.

Cancer - 1 Dec 2012

Italiano Antoine, Chen Chun-Liang, Thomas Rachael, Breen Matthew, Bonnet Françoise, Sevenet Nicolas, Longy Michel, Maki Robert G, Coindre Jean-Michel, Antonescu Cristina R

Abstract excerpt

BACKGROUND: The p53 and phosphoinositide-3-kinase, catalytic, alpha polypeptide/v-akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorp...

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Share to Class I Phosphatidylinositol 3-Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-mdm2

Share to PTEN Phosphohydrolase

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 22648906
DOI: 10.1002/cncr.27614
PMCID: PMC3434269

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22648906-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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