Article
Initiation of V(D)J recombination in vivo: role of recombination signal sequences in formation of single and paired double-strand breaks.
The EMBO journal - 15 May 1997
Steen S B, Gomelsky L, Speidel S L, Roth D B
Abstract excerpt
In V(D)J recombination, double-strand breaks (DSBs) are introduced at recombination signal sequences (RSSs) which consist of three distinct elements: a heptamer, a 12 or 23 nucleotide spacer and a nonamer. Efficient DSB formation requires a 12/23 RSS pair and occurs at both RSS in a temporally coupled fashion (coupled cleavage). It remains unknown which RSS elements are important for coupled cleavage....
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