Conservation of sequence in recombination signal sequence spacers

doi:10.1093/nar/22.10.1785

Article

Conservation of sequence in recombination signal sequence spacers

1 Jan 1994

Abstract excerpt

The variable domains of immunoglobulins and T cell receptors are assembled through the somatic, site specific recombination of multiple germline segments (V, D, and J segments) or V(D)J rearrangement. The recombination signal sequence (RSS) is necessary and sufficient for cell type specific targeting of the V(D)J rearrangement machinery to these germline segments. Previously, the RSS has been described as...

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