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Article

Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.

Nucleic acids research - 1 Apr 2009

Kumar Sushil, Swanson Patrick C

Abstract excerpt

The RAG proteins initiate V(D)J recombination by mediating synapsis and cleavage of two different antigen receptor gene segments through interactions with their flanking recombination signal sequences (RSS). The protein-DNA complexes that support this process have mainly been studied using RAG-RSS complexes assembled using oligonucleotide substrates containing a single RSS that are paired in trans to promote...

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Source

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Identifiers

PMID: 19233873
DOI: 10.1093/nar/gkp047
PMCID: PMC2673416

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.PMID 19233873Read ↗

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Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.Semantic proximity Read ↗

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