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Article

Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.

Genes & development - 1 Aug 2002

Tsai Chia-Lun, Drejer Anna H, Schatz David G

Abstract excerpt

In addition to creating the DNA double strand breaks that initiate V(D)J recombination, the RAG proteins are thought to play a critical role in the joining phase of the reaction. One such role, suggested by in vitro studies, might be to ensure the structural integrity of postcleavage complexes, but the significance of such a function in vivo is unknown. We have identified RAG1 mutants that are proficient in DNA...

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Source

Open in PubMed Open full text

Identifiers

PMID: 12154124
DOI: 10.1101/gad.984502
PMCID: PMC186421

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination.PMID 12154124Read ↗

Understanding how the V(D)J recombinase catalyzes transesterification: distinctions between DNA cleavage and transposition.Semantic proximity Read ↗

The DDE motif in RAG-1 is contributed in trans to a single active site that catalyzes the nicking and transesterification steps of V(D)J recombination.Semantic proximity Read ↗

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.Semantic proximity Read ↗

Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.Semantic proximity Read ↗

Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.Semantic proximity Read ↗

RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.Semantic proximity Read ↗

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How to make ends meet in V(D)J recombination.Semantic proximity Read ↗

Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.Semantic proximity Read ↗

Requirements for DNA hairpin formation by RAG1/2.Semantic proximity Read ↗

The end-joining reaction in V(D)J recombination.Semantic proximity Read ↗

Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Semantic proximity Read ↗

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