Article
Does mutation of transforming growth factor-beta type II receptor gene play an important role in colorectal polyps?
Digestive diseases and sciences - 1 Sept 1999
Togo G, Okamoto M, Shiratori Y, Yamaji H, Kato J, Matsumura M, Sano T, Motojima T, Omata M
Abstract excerpt
Mutations in the transforming growth factor-beta type II receptor (RII) gene that remain uncorrected due to mutation and inactivation of mismatch repair genes play an important role in hereditary nonpolyposis colorectal cancer (HNPCC) and in a subset of sporadic colorectal cancers. Some colorectal cancers develop from colorectal polyps. To elucidate the role of the RII gene in the generation of colorectal polyps,...
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