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Article

Human deoxycytidine kinase as a conditional mutator in Escherichia coli.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 Mar 1997

Bouzon M, Marlière P

Abstract excerpt

The chemical diversification of DNA precursors was undertaken in Escherichia coli by expressing the human gene for deoxycytidine kinase, and supplying such recombinant strains with nucleoside analogues bearing an altered base or sugar. Arabinocytidine and dideoxycytidine thus became highly toxic to E. coli in the sub-millimolar range. Deoxynucleosides bearing isoadenine (2-aminopurine) and isoguanine...

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PMID: 9183439
DOI: 10.1016/s0764-4469(97)86928-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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