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Article

Retrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activation.

PLoS genetics - 1 Aug 2012

Rossolillo Paola, Winter Flore, Simon-Loriere Etienne, Gallois-Montbrun Sarah, Negroni Matteo

Abstract excerpt

In evolution strategies aimed at isolating molecules with new functions, screening for the desired phenotype is generally performed in vitro or in bacteria. When the final goal of the strategy is the modification of the human cell, the mutants selected with these preliminary screenings may fail to confer the desired phenotype, due to the complex networks that regulate gene expression in higher eukaryotes. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22927829
DOI: 10.1371/journal.pgen.1002904
PMCID: PMC3426553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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