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Article

Potent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine Kinase.

PloS one - 1 Jan 2015

Coulibaly Safiatou T, Rossolillo Paola, Winter Flore, Kretzschmar Franziska K, Brayé Mélanie, Martin Darren P, Lener Daniela, Negroni Matteo

Abstract excerpt

Identifying enzymes that, once introduced in cancer cells, lead to an increased efficiency of treatment constitutes an important goal for biomedical applications. Using an original procedure whereby mutant genes are generated based on the use of conditional lentivector genome mobilisation, we recently described, for the first time, the identification of a human deoxycytidine kinase (dCK) mutant (G12) that...

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Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytarabine

Share to Deoxycytidine

Share to Drug Resistance, Neoplasm

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Source

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Identifiers

PMID: 26485161
DOI: 10.1371/journal.pone.0140741
PMCID: PMC4618062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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