Article
Escherichia coli strains (ndk) lacking nucleoside diphosphate kinase are powerful mutators for base substitutions and frameshifts in mismatch-repair-deficient strains.
Genetics - 1 Sept 2002
Miller Jeffrey H, Funchain Pauline, Clendenin Wendy, Huang Tiffany, Nguyen Anh, Wolff Erika, Yeung Annie, Chiang Ju-Huei, Garibyan Lilit, Slupska Malgorzata M, Yang Hanjing
Abstract excerpt
Nucleoside diphosphate (NDP) kinase is one of the enzymes that maintains triphosphate pools. Escherichia coli strains (ndk) lacking this enzyme have been shown to be modest base substitution mutators, and two members of the human family of NDP kinases act as tumor suppressors. We show here that in E. coli strains lacking NDP kinase high levels of mispairs are generated, but most of these are corrected by the...
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