Article
Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Roldán-Arjona T, Wei Y F, Carter K C, Klungland A, Anselmino C, Wang R P, Augustus M, Lindahl T
Abstract excerpt
The major mutagenic base lesion in DNA caused by exposure to reactive oxygen species is 8-hydroxyguanine (8-oxo-7, 8-dihydroguanine). In bacteria and Saccharomyces cerevisiae, this damaged base is excised by a DNA glycosylase with an associated lyase activity for chain cleavage. We have cloned, s...
Topics
- Amino Acid Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 3
- Cloning, Molecular
- DNA Glycosylases
- DNA, Complementary
- DNA-Formamidopyrimidine Glycosylase
- Escherichia coli
- Escherichia coli Proteins
- Humans
- Molecular Sequence Data
- N-Glycosyl Hydrolases
- Phenotype