Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.

Journal of bacteriology - 1 Nov 2008

Gawel Damian, Hamilton Michael D, Schaaper Roel M

Abstract excerpt

A novel mutator locus in Escherichia coli was identified from a collection of random transposon insertion mutants. Several mutators in this collection were found to have an insertion in the dgt gene, encoding a previously characterized dGTP triphosphohydrolase. The mutator activity of the dgt mutants displays an unusual specificity. Among the six possible base pair substitutions in a lacZ reversion system, the...

Topics

Chromosomes, Bacterial
DNA Transposable Elements
Escherichia coli
Escherichia coli Proteins
Models, Genetic
Mutation
Phosphoric Monoester Hydrolases
Rec A Recombinases

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18776019
DOI: 10.1128/JB.00935-08
PMCID: PMC2580694

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mutator of Escherichia coli carrying a defect in the dgt gene, encoding a dGTP triphosphohydrolase.PMID 18776019Read ↗

Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains.Semantic proximity Read ↗

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.Semantic proximity Read ↗

The mutT defect does not elevate chromosomal fragmentation in Escherichia coli because of the surprisingly low levels of MutM/MutY-recognized DNA modifications.Semantic proximity Read ↗

The role of the mutT gene of Escherichia coli in maintaining replication fidelitySemantic proximity Read ↗

mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions.Semantic proximity Read ↗

The interaction of the Escherichia coli mutD and mutT pathways in the prevention of A:T-->C:G transversions.Semantic proximity Read ↗

DNA methylation alters the pattern of spontaneous mutation in Escherichia coli cells (mutD) defective in DNA polymerase III proofreading.Semantic proximity Read ↗

Specificity of Escherichia coli mutD and mutL mutator strains.Semantic proximity Read ↗

Detection of DNA replication errors and 8-oxo-dGTP-mediated mutations in E. coli by Duplex DNA Sequencing.Semantic proximity Read ↗

Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity.Semantic proximity Read ↗

Increased A:T-->C:G mutations in the mutT strain upon 8-hydroxy-dGTP treatment: direct evidence for MutT involvement in the prevention of mutations by oxidized dGTP.Semantic proximity Read ↗

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.