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Article

A conditional-lethal translation termination defect in a sup45 mutant of the yeast Saccharomyces cerevisiae.

European journal of biochemistry - 1 May 1997

Stansfield I, Kushnirov V V, Jones K M, Tuite M F

Abstract excerpt

Genetic studies have indicated that the product of the yeast SUP45 gene encodes a component of the translational-termination machinery. In higher eukaryotes, genes similar to SUP45 encode eukaryote release factor 1 (eRF1), which has a stop-codon-dependent peptidyl-release activity. Using a conditional-lethal mutant allele of SUP45 (sup45-2) and a combination of in vivo and in vitro approaches, we demonstrate that...

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Identifiers

PMID: 9182990
DOI: 10.1111/j.1432-1033.1997.00557.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A conditional-lethal translation termination defect in a sup45 mutant of the yeast Saccharomyces cerevisiae.PMID 9182990Read ↗

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.Semantic proximity Read ↗

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Inactivation of NMD increases viability of sup45 nonsense mutants in Saccharomyces cerevisiae.Semantic proximity Read ↗

N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination.Semantic proximity Read ↗

Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.Semantic proximity Read ↗

N-terminal extension of Saccharomyces cerevisiae translation termination factor eRF3 influences the suppression efficiency of sup35 mutations.Semantic proximity Read ↗

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.Semantic proximity Read ↗

The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae.Semantic proximity Read ↗

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