Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel mutant of the Sup35 protein of Saccharomyces cerevisiae defective in translation termination and in GTPase activity still supports cell viability.

BMC molecular biology - 11 Feb 2008

Fabret Céline, Cosnier Bruno, Lekomtsev Sergey, Gillet Sylvie, Hatin Isabelle, Le Maréchal Pierre, Rousset Jean Pierre

Abstract excerpt

BACKGROUND: When a stop codon is located in the ribosomal A-site, the termination complex promotes release of the polypeptide and dissociation of the 80S ribosome. In eukaryotes two proteins eRF1 and eRF3 play a crucial function in the termination process. The essential GTPase Sup35p, the eRF3 release factor of Saccharomyces cerevisiae is highly conserved. In particular, we observed that all eRF3 homologs share a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP-Dependent Protein Kinases
Share to GTP Phosphohydrolases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Peptide Chain Termination, Translational

Share to Peptide Termination Factors

Share to Phosphorylation

Share to Prions

Share to Ribosomes

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18267004
DOI: 10.1186/1471-2199-9-22
PMCID: PMC2259375

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel mutant of the Sup35 protein of Saccharomyces cerevisiae defective in translation termination and in GTPase activity still supports cell viability.PMID 18267004Read ↗

N-terminal region of Saccharomyces cerevisiae eRF3 is essential for the functioning of the eRF1/eRF3 complex beyond translation termination.Semantic proximity Read ↗

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.Semantic proximity Read ↗

N-terminal extension of Saccharomyces cerevisiae translation termination factor eRF3 influences the suppression efficiency of sup35 mutations.Semantic proximity Read ↗

Viable nonsense mutants for the essential gene SUP45 of Saccharomyces cerevisiae.Semantic proximity Read ↗

The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae.Semantic proximity Read ↗

The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae.Semantic proximity Read ↗

A genetic approach for analyzing the co-operative function of the tRNA mimicry complex, eRF1/eRF3, in translation termination on the ribosome.Semantic proximity Read ↗

[The influence of mutations at ATG triplets of the open reading frame SUP35 on viability of the yeast Saccharomyces cerevisiae].Semantic proximity Read ↗

[SFP1 controls translation termination in Saccharomyces cerevisiae via regulation of the Sup35p (eRF3) level].Semantic proximity Read ↗

A conditional-lethal translation termination defect in a sup45 mutant of the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction.Semantic proximity Read ↗

Structural insights into eRF3 and stop codon recognition by eRF1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.