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Article

Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.

RNA (New York, N.Y.) - 1 Sept 2000

Bertram G, Bell H A, Ritchie D W, Fullerton G, Stansfield I

Abstract excerpt

Eukaryote ribosomal translation is terminated when release factor eRF1, in a complex with eRF3, binds to one of the three stop codons. The tertiary structure and dimensions of eRF1 are similar to that of a tRNA, supporting the hypothesis that release factors may act as molecular mimics of tRNAs. To identify the yeast eRF1 stop codon recognition domain (analogous to a tRNA anticodon), a genetic screen was...

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Identifiers

PMID: 10999601
DOI: 10.1017/s1355838200000777
PMCID: PMC1369997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.PMID 10999601Read ↗

Two-step model of stop codon recognition by eukaryotic release factor eRF1.Semantic proximity Read ↗

Genetic analysis of L123 of the tRNA-mimicking eukaryote release factor eRF1, an amino acid residue critical for discrimination of stop codons.Semantic proximity Read ↗

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Structural insights into eRF3 and stop codon recognition by eRF1.Semantic proximity Read ↗

Transcriptome-wide investigation of stop codon readthrough in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.Semantic proximity Read ↗

Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1.Semantic proximity Read ↗

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C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction.Semantic proximity Read ↗

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