Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.

doi:10.1017/s1355838200000777

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Article

Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.

RNA (New York, N.Y.) - 1 Sept 2000

Bertram G, Bell H A, Ritchie D W, Fullerton G, Stansfield I

Abstract excerpt

Eukaryote ribosomal translation is terminated when release factor eRF1, in a complex with eRF3, binds to one of the three stop codons. The tertiary structure and dimensions of eRF1 are similar to that of a tRNA, supporting the hypothesis that release factors may act as molecular mimics of tRNAs. To identify the yeast eRF1 stop codon recognition domain (analogous to a tRNA anticodon), a genetic screen was...

Topics

Alleles
Amino Acid Sequence
Blotting, Western
Codon, Terminator
Conserved Sequence
Escherichia coli
Eukaryotic Cells
Models, Molecular
Molecular Sequence Data
Mutagenesis, Site-Directed
Peptide Termination Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prokaryotic Cells

Protein Biosynthesis

Protein Conformation

Ribosomes

Saccharomyces cerevisiae

Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 10999601
DOI: 10.1017/s1355838200000777
PMCID: PMC1369997

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Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.PMID 10999601Read ↗

Two-step model of stop codon recognition by eukaryotic release factor eRF1.Semantic proximity Read ↗

Genetic analysis of L123 of the tRNA-mimicking eukaryote release factor eRF1, an amino acid residue critical for discrimination of stop codons.Semantic proximity Read ↗

Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast.Semantic proximity Read ↗

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Transcriptome-wide investigation of stop codon readthrough in <i>Saccharomyces cerevisiae</i>Semantic proximity Read ↗

The C-terminus of eRF1 defines a functionally important domain for translation termination in Saccharomyces cerevisiae.Semantic proximity Read ↗

Molecular dissection of translation termination mechanism identifies two new critical regions in eRF1.Semantic proximity Read ↗

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C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction.Semantic proximity Read ↗

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