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Article

PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer's disease patients.

Neurobiology of aging - 1 Dec 2009

Belbin Olivia, Beaumont Helen, Warden Donald, Smith A David, Kalsheker Noor, Morgan Kevin

Abstract excerpt

Mutations in amyloid precursor protein (APP) and presenilin (PSEN) genes are known to cause familial early-onset Alzheimer's disease (AD), which account for around 5% of AD cases. Genetic associations for the remaining "sporadic" cases, other than the risks associated with the apolipoprotein (APOE) epsilon4 allele are currently not fully established. The aim of this study was to investigate whether single...

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Source

Identifiers

PMID: 18403054
DOI: 10.1016/j.neurobiolaging.2008.02.013

Genes

PSEN1
APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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