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Article

Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample.

European journal of human genetics : EJHG - 1 Jan 2000

van Duijn C M, Cruts M, Theuns J, Van Gassen G, Backhovens H, van den Broeck M, Wehnert A, Serneels S, Hofman A, Van Broeckhoven C

Abstract excerpt

Genetic association has been reported between a di-allelic polymorphism in intron 8 of presenilin-1 (PSEN1) and Alzheimer's disease (AD) in some studies but not in others. In a population-based series of 102 patients with early onset AD and 118 community controls we examined whether polymorphisms in linkage disequilibrium with intron8 of PSEN1 may explain the association. In addition to the intron 8 polymorphism...

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Source

Identifiers

PMID: 10573013
DOI: 10.1038/sj.ejhg.5200373

Genes

PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample.PMID 10573013Read ↗

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No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a Tunisian population.Semantic proximity Read ↗

No association between an intronic polymorphism in the presenilin-1 gene and Alzheimer disease in a German population.Semantic proximity Read ↗

Two polymorphisms of presenilin-2 gene (PSEN2) 5' regulatory region are not associated with Alzheimer's disease (AD) in the Polish population.Semantic proximity Read ↗

No association or linkage between an intronic polymorphism of presenilin-1 and sporadic or late-onset familial Alzheimer disease.Semantic proximity Read ↗

An intronic rare mutation in Presenilin-1 (PSEN-1) gene may be involved in the developement of Alzheimer’s diseaseSemantic proximity Read ↗

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The 4,752 C/T polymorphism in the presenilin 1 gene increases the risk of Alzheimer's disease in apolipoprotein E4 carriers.Semantic proximity Read ↗

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group.Semantic proximity Read ↗

Association between presenilin-1 Glu318Gly mutation and familial Alzheimer's disease in the Australian population.Semantic proximity Read ↗

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