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Article

Clinical significance of different types of p53 gene alteration in surgically treated prostate cancer

13 Feb 2014

Abstract excerpt

Despite a multitude of p53 immunohistochemistry (IHC) studies, data on the combined effect of nuclear p53 protein accumulation and TP53 genomic inactivation are lacking for prostate cancer. A tissue microarray including 11,152 prostate cancer samples was analyzed by p53 IHC and fluorescence in situ hybridization. Nuclear p53 accumulation was found in 10.1% of patients including 1.4% with high-level and 8.7% with...

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PMID: 24523142
DOI: 10.1002/ijc.28784

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