Article
Overexpression of p53 in prostate carcinoma is associated with improved overall survival but not predictive of response to radiotherapy.
International journal of oncology - 1 Oct 2000
Incognito L S, Cazares L H, Schellhammer P F, Kuban D A, Van Dyk E O, Moriarty R P, Wright G L, Somers K D
Abstract excerpt
p53 gene mutations are among the most common specific genetic alterations in human cancer. Inactivation of p53 and subsequent protein accumulation has been implicated in a variety of human malignancies and associated with prostate cancer progression. In this study, we assessed p53 protein overexpression and gene mutations in prostate carcinoma and investigated associations between p53 alterations and...
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