Article
Association between the low density lipoprotein receptor-related protein (LRP) and Alzheimer's disease.
Neuroscience letters - 9 May 1997
Wavrant-DeVrièze F, Pérez-Tur J, Lambert J C, Frigard B, Pasquier F, Delacourte A, Amouyel P, Hardy J, Chartier-Harlin M C
Abstract excerpt
Alzheimer's disease (AD) is the most common neurodegenerative disorder affecting elderly people. It usually occurs after 65 years old (late-onset AD). The epsilon4 allele of apolipoprotein E (APOE) gene is a risk factor which contributes about 50% of the genetic risk for this form of the disease. The low density lipoprotein receptor-related protein (LRP) is a major receptor for APOE which is found in the senile...
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