Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

doi:10.1016/s0304-3940(98)00141-4

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Article

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

Neuroscience letters - 13 Mar 1998

Kamboh M I, Ferrell R E, DeKosky S T

Abstract excerpt

The E*4 allele of apolipoprotein E (APOE) is a major risk factor for Alzheimer's disease (AD) but the underlying mechanism is unknown. The low density lipoprotein receptor-related protein (LRP) is directly involved in APOE metabolism and therefore may alter the risk of AD associated with APOE. Tw...

Topics

Age of Onset
Aged
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Exons
Female
Genotype
Humans
Low Density Lipoprotein Receptor-Related Protein-1
Male
Microsatellite Repeats
Point Mutation
Polymorphism, Genetic
Receptors, Immunologic
Receptors, LDL
Reference Values

Source

Open in PubMed

Identifiers

PMID: 9572586
DOI: 10.1016/s0304-3940(98)00141-4

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9572586-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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