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LDL receptor-related protein (LRP) in Alzheimer's disease: Towards a unified theory of pathogenesis

1 Jan 2000

Abstract excerpt

To date, mutations in three genes, beta-amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2), have been found to be causally related to familial Alzheimer's disease (AD). In addition, polymorphisms in three other genes (among others), apolipoprotein E (apoE), alpha2-macroglobulin (alpham), and the low density lipoprotein receptor-related protein (LRP), are implicated to contribute to AD...

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PMID: 10936878
DOI: 10.1002/1097-0029(20000815)50:4<268::aid-jemt3>3.0.co;2-1

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