Article
Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.
Archives of neurology - 1 Oct 1997
Clatworthy A E, Gomez-Isla T, Rebeck G W, Wallace R B, Hyman B T
Abstract excerpt
BACKGROUND: The apolipoprotein E epsilon 4 (ApoE epsilon 4) allele is associated with an increased risk for development of Alzheimer disease (AD). We hypothesized that polymorphisms in proteins that interact with ApoE also might have an impact on the likelihood of AD developing. We examined a pol...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Brain
- Cohort Studies
- Gene Frequency
- Genotype
- Humans
- Low Density Lipoprotein Receptor-Related Protein-1
- Middle Aged
- Neurofibrillary Tangles
- Neurons
- Polymorphism, Genetic
- Receptors, Immunologic
- Reference Values