Article
Influence of receptor density on the patterns of beta2-adrenocepter desensitization.
European journal of pharmacology - 12 May 1997
Rousseau G, Guilbault N, Da Silva A, Mouillac B, Chidiac P, Bouvier M
Abstract excerpt
Sustained stimulation of the beta2-adrenoceptor leads to a desensitization of the receptor-mediated adenylyl cyclase stimulation. While desensitization promoted by nanomolar concentrations of isoproterenol involves the phosphorylation of the beta2-adrenoceptor by protein kinase A alone, both prot...
Topics
- Adenylyl Cyclases
- Adrenergic beta-2 Receptor Antagonists
- Adrenergic beta-Agonists
- Animals
- Bucladesine
- Cells, Cultured
- Cyclic AMP-Dependent Protein Kinases
- Humans
- Isoproterenol
- L Cells
- Membranes
- Mice
- Phenotype
- Plasmids
- Radioligand Assay
- Receptors, Adrenergic, beta-2