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Article

Influence of receptor density on the patterns of beta2-adrenocepter desensitization.

European journal of pharmacology - 12 May 1997

Rousseau G, Guilbault N, Da Silva A, Mouillac B, Chidiac P, Bouvier M

Abstract excerpt

Sustained stimulation of the beta2-adrenoceptor leads to a desensitization of the receptor-mediated adenylyl cyclase stimulation. While desensitization promoted by nanomolar concentrations of isoproterenol involves the phosphorylation of the beta2-adrenoceptor by protein kinase A alone, both protein kinase A- and beta-adrenoceptor kinase-mediated phosphorylation leading to the binding of beta-arrestin contribute...

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Identifiers

PMID: 9178658
DOI: 10.1016/s0014-2999(97)00138-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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