Article
Intact cell binding properties of cells expressing altered beta-adrenergic receptors.
Molecular pharmacology - 1 Feb 1994
Zhu S J, Toews M L
Abstract excerpt
During the course of equilibrium competition binding assays with intact cells, agonists induce conversion of beta-adrenergic receptors (BARs) from a native form with high affinity for agonists to a form with a markedly lower apparent affinity. The roles of receptor internalization, receptor-Gs coupling, and receptor phosphorylation in this agonist-induced conversion to the low affinity form were investigated....
Topics
- Adrenergic beta-Agonists
- Adrenergic beta-Antagonists
- Animals
- Binding, Competitive
- Cell Line
- Cricetinae
- Cricetulus
- Cyclic AMP-Dependent Protein Kinases
- Isoproterenol
- L Cells
- Metoprolol