Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors.

Article

Distinct receptor domains determine subtype-specific coupling and desensitization phenotypes for human beta1- and beta2-adrenergic receptors.

Molecular pharmacology - 1 Apr 1996

Rousseau G, Nantel F, Bouvier M

Abstract excerpt

Human beta1- and beta2-adrenergic receptor (beta1 AR and beta2 AR) coupling and desensitization characteristics were compared in defined heterologous expression systems. Significant differences in the coupling efficacies of the two subtypes were found in both Chinese hamster fibroblasts and murin...

Topics

Adenylyl Cyclases
Animals
Cricetinae
Cricetulus
Humans
Isoproterenol
Mice
Phenotype
Receptors, Adrenergic, beta-1
Receptors, Adrenergic, beta-2

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.