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Article

Cardiac β2-Adrenergic Receptor Phosphorylation at Ser355/356 Regulates Receptor Internalization and Functional Resensitization.

PloS one - 1 Jan 2016

Fan Xiaofang, Gu Xuejiang, Zhao Ru, Zheng Qingqing, Li Lan, Yang Wenbing, Ding Lu, Xue Feng, Fan Junming, Gong Yongsheng, Wang Yongyu

Abstract excerpt

Previous studies have demonstrated that β2-adrenergic receptors (β2ARs) can be phosphorylated by G protein-coupled receptor kinases (GRKs) and protein kinase A (PKA), affecting β2AR internalization and desensitization. However, the exact physiological function of β2ARs in cardiomyocytes is unknown. In this study, we showed that neonatal mouse cardiomyocytes had different contraction and internalization responses...

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Identifiers

PMID: 27541735
DOI: 10.1371/journal.pone.0161373
PMCID: PMC4991819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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