Article
Beta 2-adrenergic receptor mutants reveal structural requirements for the desensitization observed with long-term epinephrine treatment.
Molecular pharmacology - 1 Sept 1993
Proll M A, Clark R B, Butcher R W
Abstract excerpt
In the present study wild-type and various mutant hamster beta 2-adrenergic receptors (beta ARs) expressed in L cells were used to examine potential molecular mechanisms involved in the desensitization of hormonal stimulation of adenylyl cyclase observed after long term exposure to low concentrat...
Topics
- Adenylyl Cyclases
- Alprostadil
- Animals
- Colforsin
- Cricetinae
- Epinephrine
- L Cells
- Magnesium
- Mice
- Mutation
- Receptors, Adrenergic, beta
- Time Factors