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Article

Beta 2-adrenergic receptor mutants reveal structural requirements for the desensitization observed with long-term epinephrine treatment.

Molecular pharmacology - 1 Sept 1993

Proll M A, Clark R B, Butcher R W

Abstract excerpt

In the present study wild-type and various mutant hamster beta 2-adrenergic receptors (beta ARs) expressed in L cells were used to examine potential molecular mechanisms involved in the desensitization of hormonal stimulation of adenylyl cyclase observed after long term exposure to low concentrations of epinephrine. The mutant beta ARs included deletion mutants, D(259-262)beta AR and D(343-348)beta AR, that lack...

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PMID: 8396717

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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