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Article

Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization.

The Journal of biological chemistry - 14 Nov 2008

Krasel Cornelius, Zabel Ulrike, Lorenz Kristina, Reiner Susanne, Al-Sabah Suleiman, Lohse Martin J

Abstract excerpt

Homologous desensitization of beta2-adrenergic and other G-protein-coupled receptors is a two-step process. After phosphorylation of agonist-occupied receptors by G-protein-coupled receptor kinases, they bind beta-arrestins, which triggers desensitization and internalization of the receptors. Because it is not known which regions of the receptor are recognized by beta-arrestins, we have investigated beta-arrestin...

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Source

Identifiers

PMID: 18801735
DOI: 10.1074/jbc.M806086200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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