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Article

Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway.

Molecular pharmacology - 1 Nov 2000

Seibold A, Williams B, Huang Z F, Friedman J, Moore R H, Knoll B J, Clark R B

Abstract excerpt

The human beta(2)-adrenergic receptor (betaAR) is rapidly desensitized in response to saturating concentrations of agonist by G protein-coupled receptor kinases (GRKs) and cAMP-dependent protein kinase A (PKA) phosphorylation of the betaAR, followed by beta-arrestin binding and receptor internalization. betaAR sites phosphorylated by GRK in vivo have not yet been identified. In this study, we examined the role of...

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Source

Identifiers

PMID: 11040066
DOI: 10.1124/mol.58.5.1162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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