Article
Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation.
Genetics - 1 Jun 1997
Eisenmann D M, Kim S K
Abstract excerpt
The Caenorhabditis elegans let-60 gene encodes a Ras protein that mediates induction of the hermaphrodite vulva. To better understand how mutations constitutively activate Ras and cause unregulated cell division, we have characterized ga89, a temperature-sensitive, gain-of-function mutation in le...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Cell Division
- Female
- GTP Phosphohydrolases
- GTPase-Activating Proteins
- Gene Expression Regulation, Developmental
- Genes, ras
- Guanine Nucleotide Exchange Factors
- Helminth Proteins
- Humans
- Mutation
- Phenotype
- Proteins
- Signal Transduction
- Temperature