Article
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.
Cell - 15 Dec 1995
Kornfeld K, Hom D B, Horvitz H R
Abstract excerpt
By screening for mutations that suppress the vulval defects caused by a constitutively active let-60 ras gene, we identified six loss-of-function alleles of ksr-1, a novel C. elegans gene. Our genetic analysis showed ksr-1 positively mediates Ras signaling and functions downstream of or in parallel to let-60. In the absence of ksr-1 function, normal Ras signaling is impaired only slightly, suggesting ksr-1 may...
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