Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene.

doi:10.1101/gad.5.12a.2188

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Article

Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene.

Genes & development - 1 Dec 1991

Han M, Sternberg P W

Abstract excerpt

The let-60 gene of Caenorhabditis elegans controls the choice between vulval and hypodermal differentiation in response to an inductive signal from the gonad. let-60 encodes a ras protein that acts downstream of the let-23 receptor tyrosine kinase in a signal transduction pathway. Dominant-negative mutations of let-60 [let-60(dn)] cause a reduction of the gene activity in let-60(dn)/+ heterozygotes and a...

Topics

Animals
Animals, Genetically Modified
Arginine
Asparagine
Caenorhabditis
Caenorhabditis elegans Proteins
Cell Differentiation
Codon
Female
Gene Expression Regulation
Genes, Dominant
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genotype

Guanine Nucleotides

Helminth Proteins

Mutation

Phenotype

Vulva

Source

Open in PubMed

Identifiers

PMID: 1748278
DOI: 10.1101/gad.5.12a.2188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1748278-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene.PMID 1748278Read ↗

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