Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis elegans.

G3 (Bethesda, Md.) - 7 Sept 2017

Sterken Mark G, van Bemmelen van der Plaat Linda, Riksen Joost A G, Rodriguez Miriam, Schmid Tobias, Hajnal Alex, Kammenga Jan E, Snoek Basten L

Abstract excerpt

The oncogenic Ras/MAPK pathway is evolutionarily conserved across metazoans. Yet, almost all our knowledge on this pathway comes from studies using single genetic backgrounds, whereas mutational effects can be highly background dependent. Therefore, we lack insight in the interplay between genetic backgrounds and the Ras/MAPK-signaling pathway. Here, we used a Caenorhabditis elegans RIL population containing a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Gene Regulatory Networks

Share to Genetic Background

Share to Mitogen-Activated Protein Kinases

Share to Quantitative Trait Loci

Share to ras Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28751501
DOI: 10.1534/g3.117.1120
PMCID: PMC5592943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras/MAPK Modifier Loci Revealed by eQTL in Caenorhabditis elegans.PMID 28751501Read ↗

Functional distinction in oncogenic Ras variant activity in Caenorhabditis elegans.Semantic proximity Read ↗

Analysis of dominant-negative mutations of the Caenorhabditis elegans let-60 ras gene.Semantic proximity Read ↗

Discovery of nonautonomous modulators of activated Ras.Semantic proximity Read ↗

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways.Semantic proximity Read ↗

A lin-45 raf enhancer screen identifies eor-1, eor-2 and unusual alleles of Ras pathway genes in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction.Semantic proximity Read ↗

SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans.Semantic proximity Read ↗

Mapping mutations in C. elegans.Semantic proximity Read ↗

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.Semantic proximity Read ↗

Systemic Regulation of RAS/MAPK Signaling by the Serotonin Metabolite 5-HIAA.Semantic proximity Read ↗

Cryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.