Article
Caenorhabditis elegans SUR-5, a novel but conserved protein, negatively regulates LET-60 Ras activity during vulval induction.
Molecular and cellular biology - 1 Aug 1998
Gu T, Orita S, Han M
Abstract excerpt
The let-60 ras gene acts in a signal transduction pathway to control vulval differentiation in Caenorhabditis elegans. By screening suppressors of a dominant negative let-60 ras allele, we isolated three loss-of-function mutations in the sur-5 gene which appear to act as negative regulators of le...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Female
- Gene Expression Regulation
- Helminth Proteins
- Humans
- Molecular Sequence Data
- Mutagenesis
- Phenotype
- Repressor Proteins
- Sequence Homology, Amino Acid
- Signal Transduction
- ras Proteins