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Article

A sequencing-based screening method identifies regulators of EGFR signaling from nonviable mutants in Caenorhabditis elegans.

Science signaling - 25 Feb 2025

Schwartz Hillel T, Sternberg Paul W

Abstract excerpt

Suppressor screens can identify genetic modifiers of biochemical pathways but generally require that the suppressed mutant be viable and fertile. We developed a screening method that obviated this requirement and enabled the identification of mutations that partially suppressed the early developmental arrest and lethality caused by loss of the epidermal growth factor (EGF) receptor ortholog LET-23 in...

Read the complete abstract on PubMed

Topics

Animals
Caenorhabditis elegans
Signal Transduction
ErbB Receptors
Caenorhabditis elegans Proteins
Mutation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

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Identifiers

PMID: 39999212
DOI: 10.1126/scisignal.adp9377
PMCID: PMC12133451

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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