Article
Ras farnesyltransferase inhibitors suppress the phenotype resulting from an activated ras mutation in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 11 Apr 1995
Hara M, Han M
Abstract excerpt
Attachment of Ras protein to the membrane, which requires farnesylation at its C terminus, is essential for its biological activity. A promising pharmacological approach of antagonizing oncogenic Ras activity is to develop inhibitors of farnesyltransferase. We use Caenorhabditis elegans vulval differentiation, which is controlled by a Ras-mediated signal transduction pathway, as a model system to test previously...
Topics
- Alkyl and Aryl Transferases
- Animals
- Caenorhabditis elegans
- Dose-Response Relationship, Drug
- Farnesyltranstransferase
- Female
- Genes, Helminth
- Genes, ras
- Gliotoxin
- Mutation
- Phenotype