Article
A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.
Molecular and cellular biology - 1 Feb 1996
Katz W S, Lesa G M, Yannoukakos D, Clandinin T R, Schlessinger J, Sternberg P W
Abstract excerpt
The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutat...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Epistasis, Genetic
- ErbB Receptors
- Female
- Helminth Proteins
- Humans
- Male
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Protein Structure, Tertiary