Article
A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog.
Molecular and cellular biology - 1 Feb 1996
Katz W S, Lesa G M, Yannoukakos D, Clandinin T R, Schlessinger J, Sternberg P W
Abstract excerpt
The let-23 gene encodes a Caenorhabditis elegans homolog of the epidermal growth factor receptor (EGFR) necessary for vulval development. We have characterized a mutation of let-23 that activates the receptor and downstream signal transduction, leading to excess vulval differentiation. This mutation alters a conserved cysteine residue in the extracellular domain and is the first such point mutation in the EGFR...
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