Article
IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations.
Genomics - 15 May 1997
Krulová M, Havelková H, Kosarová M, Holán V, Hart A A, Demant P, Lipoldová M
Abstract excerpt
Lymphocytes of mouse strains BALB/cHeA (BALB/c) and STS/A (STS) differ in the IL-2-induced proliferative response, STS being a high and BALB/c a low responder in the range of concentrations 125-2000 IE/ml. We analyzed the genetic basis of this strain difference using the recombinant congenic (RC)...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Dose-Response Relationship, Immunologic
- Genes, MHC Class II
- Genetic Linkage
- Genetic Markers
- Humans
- Hybridization, Genetic
- Interleukin-2
- Lymphocyte Activation
- Mice
- Mice, Inbred BALB C
- Recombinant Proteins
- T-Lymphocytes