Article
Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.
The Journal of experimental medicine - 21 Dec 1998
Bix M, Wang Z E, Thiel B, Schork N J, Locksley R M
Abstract excerpt
The dysregulated expression of interleukin 4 (IL-4) can have deleterious effects on the outcome of infectious and allergic diseases. Despite this, the mechanisms by which naive T cells commit to IL-4 expression during differentiation into mature effector cells remain incompletely defined. As comp...
Topics
- Animals
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Chimera
- Crosses, Genetic
- Genetic Linkage
- Hematopoietic Stem Cells
- Interleukin-4
- Interleukins
- L-Selectin
- Liver
- Lymphocyte Activation
- Mice
- Mice, Inbred Strains
- Phenotype
- Polymorphism, Genetic
- RNA, Messenger
- Receptors, Interleukin-4