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Article

Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism.

The Journal of experimental medicine - 21 Dec 1998

Bix M, Wang Z E, Thiel B, Schork N J, Locksley R M

Abstract excerpt

The dysregulated expression of interleukin 4 (IL-4) can have deleterious effects on the outcome of infectious and allergic diseases. Despite this, the mechanisms by which naive T cells commit to IL-4 expression during differentiation into mature effector cells remain incompletely defined. As compared to cells from most strains of mice, activated CD4(+) T cells from BALB mice show a bias towards IL-4 production...

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Identifiers

PMID: 9858515
DOI: 10.1084/jem.188.12.2289
PMCID: PMC2212433

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Source receipt: pubmed, retrieved 7 Sept 2026.

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