Article
Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes.
Diabetes - 1 Jun 1995
Gill B M, Jaramillo A, Ma L, Laupland K B, Delovitch T L
Abstract excerpt
Thymic and peripheral T-cells from NOD mice display a proliferative unresponsiveness on stimulation through the T-cell receptor/CD3 complex. Interleukin 4 reverses NOD T-cell unresponsiveness in vitro and prevents the onset of diabetes in vivo, suggesting a causal relationship between the T-cell...
Topics
- Animals
- Chromosome Mapping
- Cytokines
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Heterozygote
- Homozygote
- Interleukin-4
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Inbred NOD
- T-Lymphocytes