Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes.

Genes and immunity - 1 Feb 2000

Lipoldová M, Svobodová M, Krulová M, Havelková H, Badalová J, Nohýnková E, Holán V, Hart A A, Volf P, Demant P

Abstract excerpt

Susceptibility as opposed to resistance of mouse strains (e.g., BALB/c vs C57BL/6) to Leishmania major has been attributed to a defective Th1 and a predominant Th2-response, resulting in increased IL-4 and IgE production, and decreased interferon gamma (IFN gamma) production, macrophage activation and elimination of parasites. Here we report dissection of genetic and functional aspects of susceptibility to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Congenic
Share to Hybridization, Genetic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Leishmania major

Share to Leishmaniasis, Cutaneous

Share to Mice, Inbred Strains

Share to Th1 Cells

Share to Th2 Cells

Source

Identifiers

PMID: 11196712
DOI: 10.1038/sj.gene.6363660

Genes

STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes.PMID 11196712Read ↗

Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice.Semantic proximity Read ↗

Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis.Semantic proximity Read ↗

Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway.Semantic proximity Read ↗

Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.Semantic proximity Read ↗

Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis.Semantic proximity Read ↗

Genetic control of resistance to Trypanosoma brucei brucei infection in mice.Semantic proximity Read ↗

Susceptibility to tuberculosis as a complex genetic trait: analysis using recombinant congenic strains of mice.Semantic proximity Read ↗

Genes from Chagas susceptibility loci that are differentially expressed in T. cruzi-resistant mice are candidates accounting for impaired immunity.Semantic proximity Read ↗

Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice.Semantic proximity Read ↗

Localization of genes controlling resistance to trypanosomiasis in mice.Semantic proximity Read ↗

Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.Semantic proximity Read ↗

Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.